Xenograft Models for Liver Metastasis: Relationship between Tumor Morphology and Adenovirus Vector Transduction
نویسندگان
چکیده
منابع مشابه
Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection.
Pre-existing anti-adenovirus neutralizing antibodies (AdNAbs) are a major barrier in clinical gene therapy using adenovirus vectors; however, the transduction profile of adenovirus vectors in the presence of AdNAbs following intratumoral injection has not been fully examined, although such vectors are often intratumorally injected in clinical studies. In this study, we evaluated the correlation...
متن کاملSurvivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models
Survivin is highly expressed in most human tumors and fetal tissue, and absent in terminally differentiated cells. It promotes tumor cell proliferation by negatively regulating cell apoptosis and facilitating cell division. Survivin's selective expression pattern suggests that it might be a suitable target for cancer therapy, which would promote death of transformed but not normal cells. This w...
متن کاملthe relationship between critical thinking and reading strategies
during the process of reading, sometimes learners use ineffective and inefficient strategies and some factors may influence their use of strategies. perhaps critical thinking is one of these factors. this study aims to identify those categories of reading strategies that are mostly used by iranian efl learners and to see if there is any significant relationship between the critical thinking abi...
the relationship between collocational competence and listening comprehension
پس از پیدایش روش تدریس tpr توسط جیمز اشر که توجه و تآکید بسیاری بر مهارت شنیداری داشت زبانشناسان همواره در صدد یافتن راههایی برای بهبود این مهارت در زبان آموزان می باشند. از طرفی جی-آر-فرث که از پیشگامان زبانشناسی می باشد بر تآثیر لغات و بویژه گروه کلمات که اغلب در گفتار با هم می آیند (هم آیی کلمات)تأکید بسیار کرده است. به این دلیل و به منظوربررسی رابطه بین این دو عامل یعنی درک شنیداری و دانش...
15 صفحه اولThe relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models.
Understanding a compound's preclinical pharmacokinetic, pharmacodynamic, and efficacy relationship can greatly facilitate its clinical development. Bortezomib is a first-in-class proteasome inhibitor whose pharmacokinetic/pharmacodynamic parameters are poorly understood in terms of their relationship with efficacy. Here we characterized the bortezomib pharmacokinetic/pharmacodynamic/efficacy re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2004
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2004.01.021